Accumulation of okadaic acid and detoxifying enzymes in the digestive gland of Mytilus galloprovincialis during exposure to DSP

Despite the preliminary nature of this work, the results obtained suggest the involvement of the microsomal monooxygenase enzymatic system dependent on cytochrome P450 in the okadaic acid biotransformation in Mytilus galloprovincialis. Moreover, the different enzymatic correlations in males and females seem to indicate sexual differences in themetabolic pathways followed. However, to confirm this and to define other possible enzymes and pathways involved in OA degradation and elimination in mussels further studies will be required.